Adapalene/benzoyl peroxide, sold under the brand name Epiduo among others, is a fixed-dose combination medication for the treatment of severe acne vulgaris.[1][2] It consists of a combination of adapalene and benzoyl peroxide in a topical gel formulation.[1][2]
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| Combination of | |
|---|---|
| Adapalene | Retinoid |
| Benzoyl peroxide | Peroxide |
| Clinical data | |
| Trade names | Epiduo, Epiduo Forte |
| Routes of administration | Topical |
| ATC code | |
| Legal status | |
| Legal status | |
| Identifiers | |
| CAS Number | |
| KEGG | |
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It is available as a generic medication.[3]
Medical uses
editAdapalene/benzoyl peroxide is indicated for the topical treatment of acne vulgaris.[1][2]
Side effects
editResearch
editMeta-analysis of clinical trials has shown this combined therapy to be more effective than either of its ingredients by themselves.[4]
The use of adapalene/benzoyl peroxide in combination with oral antibiotics (lymecycline) has been studied;[5] the combination was well tolerated and showed an improved success rate compared to those receiving only antibiotics (47.6% vs. 33.7%, P = 0.002).
References
edit- ^ a b c d e "Epiduo- adapalene and benzoyl peroxide gel". DailyMed. 21 February 2018. Retrieved 15 May 2022.
- ^ a b c d e "Epiduo Forte- adapalene and benzoyl peroxide gel". DailyMed. 27 April 2022. Retrieved 15 May 2022.
- ^ "Competitive Generic Therapy Approvals". U.S. Food and Drug Administration (FDA). 29 June 2023. Archived from the original on 29 June 2023. Retrieved 29 June 2023.
- ^ Tan J, Gollnick HP, Loesche C, Ma YM, Gold LS (August 2011). "Synergistic efficacy of adapalene 0.1%-benzoyl peroxide 2.5% in the treatment of 3855 acne vulgaris patients". The Journal of Dermatological Treatment. 22 (4): 197–205. doi:10.3109/09546631003681094. PMID 20666678. S2CID 34631151.
- ^ Dréno B, Kaufmann R, Talarico S, Torres Lozada V, Rodríguez-Castellanos MA, Gómez-Flores M, et al. (August 2011). "Combination therapy with adapalene-benzoyl peroxide and oral lymecycline in the treatment of moderate to severe acne vulgaris: a multicentre, randomized, double-blind controlled study". The British Journal of Dermatology. 165 (2): 383–90. doi:10.1111/j.1365-2133.2011.10374.x. PMID 21495995. S2CID 21793660.
External links
edit- "Adapalene mixture with benzoyl peroxide". Drug Information Portal. U.S. National Library of Medicine.
