Immunoglobulin superfamily member 8 is a protein that in humans is encoded by the IGSF8 gene.[5][6][7] IGSF8 has also been designated as CD316 (cluster of differentiation 316). IGSF8 is an innate immune checkpoint that inhibits the cytotoxic activity of natural killer (NK) cells.[8] IGSF8 acts by binding to the Killer Ig-like Receptor KIR3DL2 (or, in mice, the analogous Klra9 receptor).[8] IGSF8 is frequently overexpressed relative to normal tissues in many cancers, included melanoma, urothelial carcinoma, and breast cancer,[8] and has been proposed as a potential therapeutic target in gliomas.[9] In normal tissues, IGSF8 is highly expressed in the brain, where it may contribute to the immune privilege of the central nervous system.[8]

IGSF8
Identifiers
AliasesIGSF8, CD316, CD81P3, EWI-2, EWI2, KCT-4, LIR-D1, PGRL, immunoglobulin superfamily member 8
External IDsOMIM: 606644; MGI: 2154090; HomoloGene: 14163; GeneCards: IGSF8; OMA:IGSF8 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001206665
NM_052868
NM_001320247

NM_080419

RefSeq (protein)

NP_001193594
NP_001307176
NP_443100

NP_536344

Location (UCSC)Chr 1: 160.09 – 160.1 MbChr 1: 172.09 – 172.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

IGSF8 as a Cancer Biomarker

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In gliomas, IGSF8 is strongly correlated with tumor grade and is a potential prognostic marker.[9] IGSF8 is enriched on ovarian cancer-derived extracellular vesicles and is a potential biomarker for the early detection of high grade serous ovarian cancer.[10]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162729Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038034Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Stipp CS, Kolesnikova TV, Hemler ME (Oct 2001). "EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily". J Biol Chem. 276 (44): 40545–54. doi:10.1074/jbc.M107338200. PMID 11504738.
  6. ^ Clark KL, Zeng Z, Langford AL, Bowen SM, Todd SC (Oct 2001). "PGRL is a major CD81-associated protein on lymphocytes and distinguishes a new family of cell surface proteins". J Immunol. 167 (9): 5115–21. doi:10.4049/jimmunol.167.9.5115. PMID 11673522.
  7. ^ "Entrez Gene: IGSF8 immunoglobulin superfamily, member 8".
  8. ^ a b c d Li, Yulong; Wu, Xiangyang; Sheng, Caibin; Liu, Hailing; Liu, Huizhu; Tang, Yixuan; Liu, Chao; Ding, Qingyang; Xie, Bin; Xiao, Xi; Zheng, Rongbin; Yu, Quan; Guo, Zengdan; Ma, Jian; Wang, Jin (May 2024). "IGSF8 is an innate immune checkpoint and cancer immunotherapy target". Cell. 187 (11): 2703–2716.e23. doi:10.1016/j.cell.2024.03.039. ISSN 0092-8674. PMID 38657602.
  9. ^ a b Ren, Jiaxing; Huang, Ping; Wang, Fei (September 2024). "IGSF8 is a potential target for the treatment of gliomas". Asian Journal of Surgery. 47 (9): 3883–3891. doi:10.1016/j.asjsur.2024.02.118.
  10. ^ Trinidad, Camille V.; Pathak, Harsh B.; Cheng, Shibo; Tzeng, Shin-Cheng; Madan, Rashna; Sardiu, Mihaela E.; Bantis, Leonidas E.; Deighan, Clayton; Jewell, Andrea; Rayamajhi, Sagar; Zeng, Yong; Godwin, Andrew K. (2023-10-26). "Lineage specific extracellular vesicle-associated protein biomarkers for the early detection of high grade serous ovarian cancer". Scientific Reports. 13 (1): 18341. Bibcode:2023NatSR..1318341T. doi:10.1038/s41598-023-44050-5. ISSN 2045-2322. PMC 10603107. PMID 37884576.

Further reading

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