Cloflubicyne

Cloflubicyne
Names
	IUPAC name 5,6-dichloro-3,3-bis(trifluoromethyl)bicyclo[2.2.1]heptane-2,2-dicarbonitrile
Identifiers
CAS Number	224790-70-9;
3D model (JSmol)	Interactive image;
ChemSpider	2328106;
PubChem CID	5067794;
CompTox Dashboard (EPA)	DTXSID80274166 ;
	InChI InChI=1S/C11H6Cl2F6N2/c12-6-4-1-5(7(6)13)9(10(14,15)16,11(17,18)19)8(4,2-20)3-21/h4-7H,1H2 Key: NTESZNJQNKSALM-UHFFFAOYSA-N;
	SMILES C1C2C(C(C1C(C2(C#N)C#N)(C(F)(F)F)C(F)(F)F)Cl)Cl;
Properties
Chemical formula	C11H6Cl2F6N2
Molar mass	351.07 g·mol−1
Hazards
	Occupational safety and health (OHS/OSH):
Main hazards	Extremely toxic
	Lethal dose or concentration (LD, LC):
LD50 (median dose)	0.1 mg/kg (intraperitoneal, mice)
LDLo (lowest published)	0.2 mg/kg (oral, rats)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Cloflubicyne is a chemical compound which is a chlorinated derivative of BIDN. It is an irreversible GABA receptor antagonist with powerful convulsant effects.^[3]^[4]^[5]^[6]

References

^ Fetisov, V.I.; Maslov, A.A.; Panarin, V.A.; Trefilov, N.V. (August 1992). "Fluoro-containing 'cage' convulsants: inhibition of gamma-aminobutyric acid induced Cl−currents". Journal of Fluorine Chemistry. 58 (2–3): 368. doi:10.1016/S0022-1139(00)80833-7.
^ Middleton, W.J; Bingham, E.M (May 1982). "Fluorine-containing 1,1-dicyanoethylenes: their preparation, diels-alder reactions, and derived norbornenes and norbornanes". Journal of Fluorine Chemistry. 20 (3): 397–418. Bibcode:1982JFluC..20..397M. doi:10.1016/S0022-1139(00)82232-0.
^ Golovko, A. I.; Sofronov, G. A.; Klyuntina, T. V. (April 1996). "Norbornan, a new irreversible ligand of the GABAA-receptor chloride channels". Bulletin of Experimental Biology and Medicine. 121 (4): 404–406. doi:10.1007/BF02446741. S2CID 35092380.
^ Golovko, A. I.; Sofronov, G. A.; Klyuntina, T. V.; Suftin, S. G.; Garbuz, L. A. (July 1996). "Norbornane-induced changes in the density of chloride-ion channels in the brain of rodents". Bulletin of Experimental Biology and Medicine. 122 (1): 660–662. doi:10.1007/BF02446014. S2CID 46036353.
^ Golovko, A. I.; Ivanov, M. B.; Klyuntina, T. V.; Sofronov, G. A.; Sviderskii, O. A.; Shilov, V. V. (January 1997). "Development of increased convulsibility in mice after a single norbornan injection". Bulletin of Experimental Biology and Medicine. 123 (1): 52–54. doi:10.1007/BF02764378. S2CID 27826524.
^ Golovko, A. I.; Ivanov, M. B.; Sviderskii, O. A.; Sofronov, G. A.; Shilov, V. V. (June 1998). "Mechanisms of kindling induced by norbornan intoxication". Bulletin of Experimental Biology and Medicine. 125 (6): 579–581. doi:10.1007/BF02445245. S2CID 26207399.

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[1] Fetisov, V.I.; Maslov, A.A.; Panarin, V.A.; Trefilov, N.V. (August 1992). "Fluoro-containing 'cage' convulsants: inhibition of gamma-aminobutyric acid induced Cl−currents". Journal of Fluorine Chemistry. 58 (2–3): 368. doi:10.1016/S0022-1139(00)80833-7.

[2] Middleton, W.J; Bingham, E.M (May 1982). "Fluorine-containing 1,1-dicyanoethylenes: their preparation, diels-alder reactions, and derived norbornenes and norbornanes". Journal of Fluorine Chemistry. 20 (3): 397–418. Bibcode:1982JFluC..20..397M. doi:10.1016/S0022-1139(00)82232-0.

[3] Golovko, A. I.; Sofronov, G. A.; Klyuntina, T. V. (April 1996). "Norbornan, a new irreversible ligand of the GABAA-receptor chloride channels". Bulletin of Experimental Biology and Medicine. 121 (4): 404–406. doi:10.1007/BF02446741. S2CID 35092380.

[4] Golovko, A. I.; Sofronov, G. A.; Klyuntina, T. V.; Suftin, S. G.; Garbuz, L. A. (July 1996). "Norbornane-induced changes in the density of chloride-ion channels in the brain of rodents". Bulletin of Experimental Biology and Medicine. 122 (1): 660–662. doi:10.1007/BF02446014. S2CID 46036353.

[5] Golovko, A. I.; Ivanov, M. B.; Klyuntina, T. V.; Sofronov, G. A.; Sviderskii, O. A.; Shilov, V. V. (January 1997). "Development of increased convulsibility in mice after a single norbornan injection". Bulletin of Experimental Biology and Medicine. 123 (1): 52–54. doi:10.1007/BF02764378. S2CID 27826524.

[6] Golovko, A. I.; Ivanov, M. B.; Sviderskii, O. A.; Sofronov, G. A.; Shilov, V. V. (June 1998). "Mechanisms of kindling induced by norbornan intoxication". Bulletin of Experimental Biology and Medicine. 125 (6): 579–581. doi:10.1007/BF02445245. S2CID 26207399.

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[5]

[6]

[1]

[2]

Cloflubicyne

See also

References

zproxy.org