DS4, DS-4, or variant, may refer to:
- DS 4, the DS-branded Citroen DS4 car
- Datsun DS-4, the Datsun (Nissan) car
- Sony DualShock 4, PlayStation 4 game controller
- DS4, a digital signal designation for 274.176 Mbit/s 4032-channel T4 lines, see Digital Signal Designation
- Dalit Shoshit Samaj Sangharsh Samiti (DS-4 or DSSSS) political organization in India