GGA1

ADP-ribosylation factor-binding protein GGA1 is a protein that in humans is encoded by the GGA1 gene.

GGA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1J2J, 1JWF, 1JWG, 1NA8, 1NAF, 1NWM, 1O3X, 1OM9, 1OXZ, 1PY1, 1UJJ, 1UJK, 1X79, 2DWX, 2DWY, 3G2S, 3G2T, 3G2U, 3G2V, 3G2W
Identifiers
Aliases	GGA1, golgi associated, gamma adaptin ear containing, ARF binding protein 1
External IDs	OMIM: 606004; MGI: 2146207; HomoloGene: 39250; GeneCards: GGA1; OMA:GGA1 - orthologs
Gene location (Human) Chr. Chromosome 22 (human) Band 22q13.1 Start 37,608,725 bp End 37,633,564 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15|15 E1 Start 78,761,390 bp End 78,778,785 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell left testis right testis endothelial cell right uterine tube mucosa of ileum right hemisphere of cerebellum Pituitary Gland gingival epithelium anterior pituitary Top expressed in granulocyte muscle of thigh lip pyloric antrum yolk sac superior frontal gyrus ventricular zone dentate gyrus of hippocampal formation granule cell primary visual cortex esophagus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein heterodimerization activity molecular function Cellular component endosome Golgi apparatus endosome membrane intracellular anatomical structure membrane intracellular membrane-bounded organelle clathrin adaptor complex nucleoplasm early endosome membrane early endosome cytosol protein-containing complex Biological process protein transport intracellular protein transport toxin transport positive regulation of protein catabolic process vesicle-mediated transport transport Golgi to plasma membrane transport protein localization protein localization to cell surface retrograde transport, endosome to Golgi Golgi to plasma membrane protein transport protein localization to ciliary membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26088 106039 Ensembl ENSG00000100083 ENSMUSG00000033128 UniProt Q9UJY5 Q8R0H9 RefSeq (mRNA) NM_001001560 NM_001001561 NM_001172687 NM_001172688 NM_013365 NM_001363771 NM_145929 RefSeq (protein) NP_001001560 NP_001166158 NP_001166159 NP_037497 NP_001350700 NP_666041 Location (UCSC) Chr 22: 37.61 – 37.63 Mb Chr 15: 78.76 – 78.78 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Members of this family are ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Interactions

GGA1 has been shown to interact with Sortilin 1, BACE2, RABEP1 and ARF3.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
• Boman AL, Zhang C, Zhu X, Kahn RA (2000). "A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi". Mol. Biol. Cell. 11 (4): 1241–55. doi:10.1091/mbc.11.4.1241. PMC 14844. PMID 10749927.
• Takatsu H, Yoshino K, Nakayama K (2000). "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochem. Biophys. Res. Commun. 271 (3): 719–25. doi:10.1006/bbrc.2000.2700. PMID 10814529.
• Zhdankina O, Strand NL, Redmond JM, Boman AL (2001). "Yeast GGA proteins interact with GTP-bound Arf and facilitate transport through the Golgi". Yeast. 18 (1): 1–18. doi:10.1002/1097-0061(200101)18:1<1::AID-YEA644>3.0.CO;2-5. PMID 11124697. S2CID 10348751.
• Puertollano R, Randazzo PA, Presley JF, et al. (2001). "The GGAs promote ARF-dependent recruitment of clathrin to the TGN". Cell. 105 (1): 93–102. doi:10.1016/S0092-8674(01)00299-9. PMID 11301005.
• Puertollano R, Aguilar RC, Gorshkova I, et al. (2001). "Sorting of mannose 6-phosphate receptors mediated by the GGAs". Science. 292 (5522): 1712–6. Bibcode:2001Sci...292.1712P. doi:10.1126/science.1060750. PMID 11387475. S2CID 30836125.
• Takatsu H, Katoh Y, Shiba Y, Nakayama K (2001). "Golgi-localizing, gamma-adaptin ear homology domain, ADP-ribosylation factor-binding (GGA) proteins interact with acidic dileucine sequences within the cytoplasmic domains of sorting receptors through their Vps27p/Hrs/STAM (VHS) domains". J. Biol. Chem. 276 (30): 28541–5. doi:10.1074/jbc.C100218200. PMID 11390366.
• Jacobsen L, Madsen P, Nielsen MS, et al. (2002). "The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding". FEBS Lett. 511 (1–3): 155–8. doi:10.1016/S0014-5793(01)03299-9. PMID 11821067. S2CID 21977507.
• Shiba T, Takatsu H, Nogi T, et al. (2002). "Structural basis for recognition of acidic-cluster dileucine sequence by GGA1". Nature. 415 (6874): 937–41. Bibcode:2002Natur.415..937S. doi:10.1038/415937a. PMID 11859376. S2CID 4395774.
• Takatsu H, Yoshino K, Toda K, Nakayama K (2002). "GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors". Biochem. J. 365 (Pt 2): 369–78. doi:10.1042/BJ20020428. PMC 1222692. PMID 11950392.
• Doray B, Bruns K, Ghosh P, Kornfeld SA (2002). "Autoinhibition of the ligand-binding site of GGA1/3 VHS domains by an internal acidic cluster-dileucine motif". Proc. Natl. Acad. Sci. U.S.A. 99 (12): 8072–7. Bibcode:2002PNAS...99.8072D. doi:10.1073/pnas.082235699. PMC 123022. PMID 12060753.
• He X, Chang WP, Koelsch G, Tang J (2002). "Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2". FEBS Lett. 524 (1–3): 183–7. doi:10.1016/S0014-5793(02)03052-1. PMID 12135764.
• Boman AL, Salo PD, Hauglund MJ, et al. (2003). "ADP-ribosylation factor (ARF) interaction is not sufficient for yeast GGA protein function or localization". Mol. Biol. Cell. 13 (9): 3078–95. doi:10.1091/mbc.E02-02-0078. PMC 124144. PMID 12221117.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mattera R, Arighi CN, Lodge R, et al. (2003). "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex". EMBO J. 22 (1): 78–88. doi:10.1093/emboj/cdg015. PMC 140067. PMID 12505986.
• Mills IG, Praefcke GJ, Vallis Y, et al. (2003). "EpsinR: an AP1/clathrin interacting protein involved in vesicle trafficking". J. Cell Biol. 160 (2): 213–22. doi:10.1083/jcb.200208023. PMC 2172650. PMID 12538641.