These are the number-one hits on the Top 100 Singles chart in 1979 as published by Cash Box magazine.
| † | Indicates best-performing single of 1979 |
| Issue date | Song | Artist |
|---|---|---|
| January 6 | "Le Freak" † | Chic |
| January 13 | ||
| January 20 | ||
| January 27 | ||
| February 3 | "Da Ya Think I'm Sexy?" | Rod Stewart |
| February 10 | ||
| February 17 | ||
| February 24 | ||
| March 3 | ||
| March 10 | "I Will Survive" | Gloria Gaynor |
| March 17 | "Tragedy" | Bee Gees |
| March 24 | ||
| March 31 | ||
| April 7 | "What a Fool Believes" | Doobie Brothers |
| April 14 | ||
| April 21 | "Knock on Wood" | Amii Stewart |
| April 28 | "Heart of Glass" | Blondie |
| May 5 | "Reunited" | Peaches & Herb |
| May 12 | ||
| May 19 | ||
| May 26 | ||
| June 2 | "Hot Stuff" | Donna Summer |
| June 9 | ||
| June 16 | ||
| June 23 | ||
| June 30 | "Ring My Bell" | Anita Ward |
| July 7 | ||
| July 14 | ||
| July 21 | "Bad Girls" | Donna Summer |
| July 28 | ||
| August 4 | ||
| August 11 | "Good Times" | Chic |
| August 18 | "My Sharona" | The Knack |
| August 25 | ||
| September 1 | ||
| September 8 | ||
| September 15 | ||
| September 22 | ||
| September 29 | "Sad Eyes" | Robert John |
| October 6 | ||
| October 13 | "Don't Stop 'til You Get Enough" | Michael Jackson |
| October 20 | "Sail On" | Commodores |
| October 27 | "Rise" | Herb Alpert |
| November 3 | ||
| November 10 | "Heartache Tonight" | Eagles |
| November 17 | "Still" | Commodores |
| November 24 | "Babe" | Styx |
| December 1 | ||
| December 8 | ||
| December 15 | "No More Tears (Enough Is Enough)" | Barbra Streisand & Donna Summer |
| December 22 | "Escape (The Pina Colada Song)" | Rupert Holmes |
| December 29 |