PLCB3

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 is an enzyme that in humans is encoded by the PLCB3 gene.

PLCB3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3OHM, 4GNK, 4QJ3, 4QJ4, 4QJ5
Identifiers
Aliases	PLCB3, phospholipase C beta 3, SMDCD
External IDs	OMIM: 600230; MGI: 104778; HomoloGene: 47960; GeneCards: PLCB3; OMA:PLCB3 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q13.1 Start 64,251,530 bp End 64,269,150 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19 A|19 5.1 cM Start 6,929,693 bp End 6,953,838 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon tendon of biceps brachii duodenum buccal mucosa cell right adrenal gland ectocervix left adrenal cortex stromal cell of endometrium right adrenal cortex right coronary artery Top expressed in crypt of lieberkuhn of small intestine duodenum jejunum lumbar spinal ganglion ileum lip left colon cumulus cell migratory enteric neural crest cell granulocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding signal transducer activity phosphoric diester hydrolase activity hydrolase activity phosphatidylinositol phospholipase C activity cadherin binding protein binding calmodulin binding phospholipase C activity Cellular component cytosol membrane nucleoplasm protein-containing complex postsynaptic cytosol Biological process intracellular signal transduction lipid metabolism inositol phosphate metabolic process lipid catabolic process regulation of systemic arterial blood pressure signal transduction Wnt signaling pathway, calcium modulating pathway G protein-coupled receptor signaling pathway inositol trisphosphate biosynthetic process phosphatidylinositol-mediated signaling release of sequestered calcium ion into cytosol Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5331 18797 Ensembl ENSG00000149782 ENSMUSG00000024960 UniProt Q01970 P51432 RefSeq (mRNA) NM_000932 NM_001184883 NM_001316314 NM_001290349 NM_008874 RefSeq (protein) NP_000923 NP_001171812 NP_001303243 NP_001277278 NP_032900 Location (UCSC) Chr 11: 64.25 – 64.27 Mb Chr 19: 6.93 – 6.95 Mb PubMed search
Wikidata
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The gene codes for the enzyme phospholipase C β3. The enzyme catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11, as well as G-beta gamma subunits.

Interactions

PLCB3 has been shown to interact with Sodium-hydrogen exchange regulatory cofactor 2.

Further reading

• Carozzi AJ, Kriz RW, Webster C, Parker PJ (1992). "Identification, purification and characterization of a novel phosphatidylinositol-specific phospholipase C, a third member of the beta subfamily". Eur. J. Biochem. 210 (2): 521–9. doi:10.1111/j.1432-1033.1992.tb17450.x. PMID 1333955.
• Cefai D, Debre P, Kaczorek M, Idziorek T, Autran B, Bismuth G (1990). "Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway". J. Clin. Invest. 86 (6): 2117–24. doi:10.1172/JCI114950. PMC 329852. PMID 1979339.
• Zauli G, Previati M, Caramelli E, Bassini A, Falcieri E, Gibellini D, Bertolaso L, Bosco D, Robuffo I, Capitani S (1995). "Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line". Eur. J. Immunol. 25 (9): 2695–700. doi:10.1002/eji.1830250944. PMID 7589147. S2CID 20562627.
• Lagercrantz J, Carson E, Phelan C, Grimmond S, Rosén A, Daré E, Nordenskjöld M, Hayward NK, Larsson C, Weber G (1995). "Genomic organization and complete cDNA sequence of the human phosphoinositide-specific phospholipase C beta 3 gene (PLCB3)". Genomics. 26 (3): 467–72. doi:10.1016/0888-7543(95)80164-H. PMID 7607669.
• Mazuruk K, Schoen TJ, Chader GJ, Rodriguez IR (1995). "Structural organization and expression of the human phosphatidylinositol-specific phospholipase C beta-3 gene". Biochem. Biophys. Res. Commun. 212 (1): 190–5. doi:10.1006/bbrc.1995.1955. PMID 7612006.
• Sinke RJ, Geurts van Kessel AG (1995). "Localization of the human phosphatidylinositol-specific phospholipase c beta 3 gene (PLCB3) within chromosome band 11q13". Genomics. 25 (2): 568–9. doi:10.1016/0888-7543(95)80060-Y. PMID 7789993.
• Chen P, Mayne M, Power C, Nath A (1997). "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases". J. Biol. Chem. 272 (36): 22385–8. doi:10.1074/jbc.272.36.22385. PMID 9278385.
• Snow BE, Hall RA, Krumins AM, Brothers GM, Bouchard D, Brothers CA, Chung S, Mangion J, Gilman AG, Lefkowitz RJ, Siderovski DP (1998). "GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain". J. Biol. Chem. 273 (28): 17749–55. doi:10.1074/jbc.273.28.17749. PMID 9651375.
• Wang S, Zhou Y, Lukinius A, Oberg K, Skogseid B, Gobl A (1998). "Molecular cloning and characterization of a cDNA encoding mouse phospholipase C-beta3". Biochim. Biophys. Acta. 1393 (1): 173–8. doi:10.1016/s0005-2760(98)00074-5. PMID 9714794.
• Mayne M, Bratanich AC, Chen P, Rana F, Nath A, Power C (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease". Neuroimmunomodulation. 5 (3–4): 184–92. doi:10.1159/000026336. PMID 9730685. S2CID 19529677.
• Haughey NJ, Holden CP, Nath A, Geiger JD (1999). "Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat". J. Neurochem. 73 (4): 1363–74. doi:10.1046/j.1471-4159.1999.0731363.x. PMID 10501179. S2CID 25410140.
• Hwang JI, Heo K, Shin KJ, Kim E, Yun C, Ryu SH, Shin HS, Suh PG (2000). "Regulation of phospholipase C-beta 3 activity by Na+/H+ exchanger regulatory factor 2". J. Biol. Chem. 275 (22): 16632–7. doi:10.1074/jbc.M001410200. PMID 10748023.
• Wang JC, Waltner-Law M, Yamada K, Osawa H, Stifani S, Granner DK (2000). "Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta". J. Biol. Chem. 275 (24): 18418–23. doi:10.1074/jbc.M910211199. PMID 10748198.
• Mayne M, Holden CP, Nath A, Geiger JD (2000). "Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages". J. Immunol. 164 (12): 6538–42. doi:10.4049/jimmunol.164.12.6538. PMID 10843712.
• Caricasole A, Sala C, Roncarati R, Formenti E, Terstappen GC (2000). "Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1)". Biochim. Biophys. Acta. 1517 (1): 63–72. doi:10.1016/S0167-4781(00)00260-8. PMID 11118617.
• Stålberg P, Lopez-Egido JR, Wang S, Gobl A, Oberg K, Skogseid B (2001). "Differentially expressed cDNAs in PLCbeta3-induced tumor suppression in a human endocrine pancreatic tumor cell line: activation of the human mismatch repair protein 3 gene". Biochem. Biophys. Res. Commun. 281 (1): 227–31. doi:10.1006/bbrc.2001.4329. PMID 11178984.
• Xia C, Bao Z, Yue C, Sanborn BM, Liu M (2001). "Phosphorylation and regulation of G-protein-activated phospholipase C-beta 3 by cGMP-dependent protein kinases". J. Biol. Chem. 276 (23): 19770–7. doi:10.1074/jbc.M006266200. PMID 11278298.
• Yue C, Sanborn BM (2001). "KN-93 inhibition of G protein signaling is independent of the ability of Ca2+/calmodulin-dependent protein kinase II to phosphorylate phospholipase Cbeta3 on 537-Ser". Mol. Cell. Endocrinol. 175 (1–2): 149–56. doi:10.1016/S0303-7207(01)00383-5. PMID 11325525. S2CID 338776.
• Bennasser Y, Badou A, Tkaczuk J, Bahraoui E (2002). "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha". Virology. 303 (1): 174–80. doi:10.1006/viro.2002.1676. PMID 12482669.