Tylosin is a macrolide antibiotic and bacteriostatic feed additive used in veterinary medicine. It has a broad spectrum of activity against Gram-positive organisms and a limited range of Gram-negative organisms.[1] It is found naturally as a fermentation product of Streptomyces fradiae.[2]
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| Trade names | Tylocine, Tylan |
| AHFS/Drugs.com | International Drug Names |
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| E number | E713 (antibiotics) |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.014.322 |
| Chemical and physical data | |
| Formula | C46H77NO17 |
| Molar mass | 916.112 g·mol−1 |
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Tylosin is used in veterinary medicine to treat bacterial infections in a wide range of species and has a high margin of safety.[3] It has also been used as a growth promotant in some species, and as a treatment for colitis in companion animals.[2]
Mode of action
editLike other macrolides, tylosin has a bacteriostatic effect on susceptible organisms, caused by inhibition of protein synthesis through binding to the 50S subunit of the bacterial ribosome.[citation needed]
Spectrum of activity
editTylosin has a wide spectrum of activity against Gram-positive bacteria including Staphylococcus, Streptococcus, Corynebacterium, and Erysipelothrix. It has a much narrower Gram-negative spectrum of activity, but has been shown to be active against Campylobacter coli, and certain spirochaetes.[4] It has also been shown to be extremely active against Mycoplasma species isolated from both mammalian and avian hosts.[3][5] The following represents MIC susceptibility data for a few medically significant pathogens:
- Mycoplasma bovis: 0.06 - 4 μg/ml[citation needed]
- Staphylococcus aureus: 0.5 - >128 μg/ml[6]
Clinical use
editTylosin has been used to treat a variety of different diseases throughout the world. Differing formulations and licensing conditions mean it may not be a recognized method of treatment for certain conditions in certain countries. In general, tylosin is licensed for the treatment of infections caused by organisms susceptible to the drug, but it has also been used as a treatment of colitis in small animals, as a growth promotant in food-producing animals, and as a way of reducing epiphora (tear staining) around the eyes of white-faced dogs.[2] In these cases, the result is positive only when using the tylosin in the form of tartrate, a chelating porphyrin. No marketing authority exists for the use of other tylosin forms as a tear-stain remover, thus it is not legal to use it for such purposes; the exception is as a prescription-only medicine of last resort by veterinarians under the cascading rule (UK) or the extra-label use rule (US).[citation needed]
Examples of bacterial infections that could potentially be treated with tylosin include respiratory infections, metritis, and acute mastitis in cattle; mastitis in sheep and goats; enteritis, pneumonia, erysipelas, and infectious arthritis in swine; and soft-tissue infections in small animals.[1][2][4][5] While tylosin may be one appropriate therapeutic choice in theory for the conditions listed above, many other antibiotics may be preferable for treating a specific infection, and tylosin will not be the first choice.
It is also used as a growth promoter for a variety of terrestrial and aquatic animals grown for human consumption.[7]
Available forms
editTylosin is available in injectable, intramammary, and oral formulations with different product ranges available in different countries.[1]
Composition
editTylosin is a mixture of four major components: tylosins A, B, C, and D. Tylosin A is considered the major component of tylosin (comprises about 90% of tylosin); however, tylosins B, C, and D contribute to the overall potency of tylosin.[8]
Precautions and contraindications
editAdministration of tylosin should be avoided in animals with a known hypersensitivity to the product, or to other macrolides.[5]
Oral administration can result in diarrhoea and gastrointestinal disturbance. This is particularly true of horses, such that it can be fatal.[9] Tylosin also has a foul taste that is difficult to disguise.
The injectable formulations of tylosin can cause pain, inflammation, and itchiness around the injection site.[citation needed]
Since tylosin has a relatively poor spectrum of activity against Gram-negative organisms, it may not be a sensible therapeutic choice in the treatment of infections caused by unknown, potentially unsusceptible organisms.[citation needed]
Drug interactions
editTylosin may increase digitalis blood levels, thus its toxicity,[5] and may be antagonistic to chloramphenicol or lincosamides.
Colorimetric assays of serum ALT and AST may be falsely elevated by macrolide antibiotics.[citation needed]
See also
editReferences
edit- ^ a b c Giguere S, Dowling PM (2006). "Tylosin". Antimicrobial Therapy in Veterinary Medicine (4th ed.). Ames, Iowa: Blackwell Pub. ISBN 978-0-8138-0656-3.
- ^ a b c d "Tylosin". marvistavet.com. Archived from the original on 10 May 2012.
- ^ a b "Tylan 200 Injectable - Product data sheet PA9063DENZP" (PDF). Elanco Animal Health.
- ^ a b Tylosin, drugs.com
- ^ a b c d "Tylosin-Tylan". petplace.com.
- ^ "Tylosin | the Antimicrobial Index Knowledgebase - TOKU-E".
- ^ Palmer FJ, Sawyers TM (September 1978). "Hyperparathyroidism, chemodectoma, thymoma, and myasthenia gravis". Archives of Internal Medicine. 138 (9): 1402–3. doi:10.1001/archinte.1978.03630340072022. PMID 28708.
- ^ Loke ML, Ingerslev F, Halling-Sørensen B, Tjørnelund J (April 2000). "Stability of Tylosin A in manure containing test systems determined by high performance liquid chromatography". Chemosphere. 40 (7): 759–65. Bibcode:2000Chmsp..40..759L. doi:10.1016/s0045-6535(99)00450-6. PMID 10705554.
- ^ "Tylan". americanlivestock.com. Archived from the original on 6 October 2011.