Protein Wnt-9b (formerly Wnt15[5]) is a protein that in humans is encoded by the WNT9B gene.[6]
The Wnt family of genes produce glycolipoproteins that are involved with signaling and developmental processes. Like other Wnt genes, Wnt-9b codes for the Wnt-9b protein which participates in the canonical Wnt/β-catenin signaling pathway. Wnt-9b is a gene found on chromosome 17 in region 17q21. It can be traced to function in the establishment of the kidneys, because Wnt9 is critical for morphogenesis of the nephron.[7] This gene can impact kidney function in more than one way. Improper expression of the gene can cause cyst development on the kidney tubules, and in mice, mutant Wnt9 genes that cause lower protein concentrations resulted in failure of the kidneys to thrive shortly after birth.[8] Wnt-9b is a gene that often expressed in the epithelial cells of the Wolfian duct in early male and female embryos. In the embryos, Wnt11 is expressed at the branching points of the kidney tubules while Wnt-9b is expressed in a higher concentration at the stalk of the tubules.[9] Wnt-9b has also been tied to the involvement of neural differentiation by induction of retinoic acid, according to the NCBI.[10]
References
edit- ^ a b c ENSG00000276799 GRCh38: Ensembl release 89: ENSG00000158955, ENSG00000276799 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018486 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Garriock RJ, Warkman AS, Meadows SM, D'Agostino S, Krieg PA (2007). "Census of vertebrate Wnt genes: isolation and developmental expression of Xenopus Wnt2, Wnt3, Wnt9a, Wnt9b, Wnt10a, and Wnt16". Developmental Dynamics. 236 (5): 1249–58. doi:10.1002/dvdy.21156. PMID 17436276. S2CID 21016668.
- ^ "Entrez Gene: Wnt9b wingless-type MMTV integration site family, member 9B".
- ^ Karner C, Chirumamilla R, Aoki S, et al. (2009). "Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis". Nat Genet. 41 (7): 793–799. doi:10.1038/ng.400. PMC 2761080. PMID 19543268.
- ^ Karner C, Chirumamilla R, Aoki S, et al. (2009). "Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis". Nat Genet. 41 (7): 793–799. doi:10.1038/ng.400. PMC 2761080. PMID 19543268.
- ^ Carroll T, Park J, Hayashi S, Majumdar A, McMahon A, et al. (2005). "Wnt9b Plays a Central Role in the Regulation of Mesenchymal to Epithelial Transitions Underlying Organogenesis of the Mammalian Urogenital System". Developmental Cell. 9 (2): 283–292. doi:10.1016/j.devcel.2005.05.016. PMID 16054034.
- ^ "WNT9B Wnt family member 9B [Homo sapiens (human)]". NCBI Genes & Expression. 2021-04-06. Retrieved 2021-04-14.
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