157 may refer to:
- 157 (year)
- 157 (number)
- UFC 157, a mixed martial arts event held by the Ultimate Fighting Championship
- ONE 157, a combat sport event produced by ONE Championship
- Radical 157, one of the 20 Kangxi radicals composed of 7 strokes meaning "foot"
- NGC 157, an intermediate spiral galaxy in the constellation of Cetus
- 157 series, a DC electric multiple unit train type
- Tatra 157, the prototype version of the Tatra 815