Abetimus (trade name Riquent) is an immunosuppressant.[1] It is a synthetic biological called a tolerogen. It is made of four double-stranded oligodeoxyribonucleotides that are attached to a carrier platform and are designed to block specific B-cell anti double stranded DNA antibodies.[2] It may also complex anti dsDNA antibodies together, therefore disabling them. This way abetimus was supposed to help treat systemic lupus erythematosus and specifically lupus nephritis.
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| Trade names | Riquent |
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| Formula | C1632H1944N610Na156O970P156S4 |
| Molar mass | 54171.35 g·mol−1 |
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It was developed by La Jolla Pharmaceutical, who applied for marketing authorisations in the mid-2000s, but the drug was never marketed in the US or in Europe.[3][4]
References
edit- ^ "Abetimus: Abetimus sodium, LJP 394". BioDrugs. 17 (3). Springer Nature Switzerland AG: 212–5. 2003. doi:10.2165/00063030-200317030-00009. PMID 12749759. S2CID 19896886.
- ^ Wallace DJ (January 2001). "Clinical and pharmacological experience with LJP-394". Expert Opinion on Investigational Drugs. 10 (1). Informa: 111–7. doi:10.1517/13543784.10.1.111. PMID 11116284. S2CID 43518002.
- ^ "Riquent Approval Status". Drugs.com. Retrieved 7 January 2017.
- ^ "Riquent". European Medicines Agency. Retrieved 7 January 2017.
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