BATF (gene)

Basic leucine zipper transcription factor, ATF-like, also known as BATF, is a protein which in humans is encoded by the BATF gene.

BATF
Identifiers
Aliases	BATF, B-ATF, BATF1, SFA-2, SFA2, basic leucine zipper ATF-like transcription factor
External IDs	OMIM: 612476; MGI: 1859147; HomoloGene: 4666; GeneCards: BATF; OMA:BATF - orthologs
Gene location (Human) Chr. Chromosome 14 (human) Band 14q24.3 Start 75,522,455 bp End 75,546,993 bp
Gene location (Mouse) Chr. Chromosome 12 (mouse) Band 12|12 D2 Start 85,733,443 bp End 85,755,861 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte blood monocyte spleen lymph node appendix palpebral conjunctiva testicle bone marrow olfactory zone of nasal mucosa Top expressed in granulocyte embryo spleen embryo lymph node blood mesenteric lymph nodes thymus parotid gland subcutaneous adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding sequence-specific DNA binding DNA-binding transcription factor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm nucleoplasm nucleus Biological process regulation of transcription by RNA polymerase II cell differentiation regulation of transcription, DNA-templated transcription, DNA-templated transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II T-helper 2 cell differentiation cytokine production DNA damage response, signal transduction by p53 class mediator myeloid dendritic cell differentiation lymphoid progenitor cell differentiation T-helper 17 cell lineage commitment cellular response to DNA damage stimulus hematopoietic stem cell differentiation isotype switching T-helper 17 cell differentiation defense response to protozoan cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10538 53314 Ensembl ENSG00000156127 ENSMUSG00000034266 UniProt Q16520 O35284 RefSeq (mRNA) NM_006399 NM_016767 RefSeq (protein) NP_006390 NP_058047 Location (UCSC) Chr 14: 75.52 – 75.55 Mb Chr 12: 85.73 – 85.76 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is a nuclear basic leucine zipper (bZIP) protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates dimerization with members of the Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events.

Mice without the BATF gene (BATF knockout mice) lacked a type of inflammatory immune cell (Th17) and were resistant to conditions that normally induces an autoimmune condition similar to multiple sclerosis.

Interactions

BATF (gene) has been shown to interact with IFI35.

Further reading

• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Deppmann CD, Thornton TM, Utama FE, Taparowsky EJ (2003). "Phosphorylation of BATF regulates DNA binding: a novel mechanism for AP-1 (activator protein-1) regulation". Biochem. J. 374 (Pt 2): 423–31. doi:10.1042/BJ20030455. PMC 1223616. PMID 12809553.
• Johansen LM, Deppmann CD, Erickson KD, Coffin WF, Thornton TM, Humphrey SE, Martin JM, Taparowsky EJ (2003). "EBNA2 and Activated Notch Induce Expression of BATF". J. Virol. 77 (10): 6029–40. doi:10.1128/JVI.77.10.6029-6040.2003. PMC 154003. PMID 12719594.
• Williams KL, Zullo AJ, Kaplan MH, Brutkiewicz RR, Deppmann CD, Vinson C, Taparowsky EJ (2003). "BATF transgenic mice reveal a role for activator protein-1 in NKT cell development". J. Immunol. 170 (5): 2417–26. doi:10.4049/jimmunol.170.5.2417. PMID 12594265.
• Echlin DR, Tae HJ, Mitin N, Taparowsky EJ (2000). "B-ATF functions as a negative regulator of AP-1 mediated transcription and blocks cellular transformation by Ras and Fos". Oncogene. 19 (14): 1752–63. doi:10.1038/sj.onc.1203491. PMID 10777209. S2CID 21006485.
• Meyer NP, Johansen LM, Tae HJ, Budde PP, Williams KL, Taparowsky EJ (1998). "Genomic organization of human B-ATF, a target for regulation by EBV and HTLV-1". Mamm. Genome. 9 (10): 849–52. doi:10.1007/s003359900881. PMID 9745044. S2CID 36362547.
• Wang X, Johansen LM, Tae HJ, Taparowsky EJ (1997). "IFP 35 forms complexes with B-ATF, a member of the AP1 family of transcription factors". Biochem. Biophys. Res. Commun. 229 (1): 316–22. doi:10.1006/bbrc.1996.1799. PMID 8954125.
• Hasegawa H, Utsunomiya Y, Kishimoto K, Tange Y, Yasukawa M, Fujita S (1996). "SFA-2, a novel bZIP transcription factor induced by human T-cell leukemia virus type I, is highly expressed in mature lymphocytes". Biochem. Biophys. Res. Commun. 222 (1): 164–70. doi:10.1006/bbrc.1996.0700. PMID 8630063.
• Dorsey MJ, Tae HJ, Sollenberger KG, Mascarenhas NT, Johansen LM, Taparowsky EJ (1996). "B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family". Oncogene. 11 (11): 2255–65. PMID 8570175.

External links

• BATF+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• FactorBook BATF
• Human BATF genome location and BATF gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.