CUL7

Cullin-7 is a RING-E3 ligase protein that in humans is encoded by the CUL7 gene.

CUL7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JNG
Identifiers
Aliases	CUL7, 3M1, KIAA0076, dJ20C7.5, cullin 7, CUL-7
External IDs	OMIM: 609577; MGI: 1913765; HomoloGene: 56683; GeneCards: CUL7; OMA:CUL7 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p21.1 Start 43,037,617 bp End 43,053,943 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17|17 C Start 46,961,263 bp End 46,975,290 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium pituitary gland anterior pituitary right uterine tube right adrenal gland right adrenal cortex right lobe of thyroid gland ventricular zone right hemisphere of cerebellum canal of the cervix Top expressed in saccule yolk sac otic vesicle otic placode umbilical cord internal carotid artery external carotid artery human fetus efferent ductule molar More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding ubiquitin protein ligase binding Cellular component cytoplasm cytosol centrosome Golgi apparatus microtubule organizing center Cul7-RING ubiquitin ligase complex perinuclear region of cytoplasm anaphase-promoting complex 3M complex cytoskeleton Biological process Golgi organization ubiquitin-dependent protein catabolic process placenta development mitotic cytokinesis proteolysis vasculogenesis IRE1-mediated unfolded protein response positive regulation of dendrite morphogenesis protein ubiquitination epithelial to mesenchymal transition viral process microtubule cytoskeleton organization regulation of mitotic nuclear division post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9820 66515 Ensembl ENSG00000044090 ENSMUSG00000038545 UniProt Q14999 Q8VE73 RefSeq (mRNA) NM_001168370 NM_014780 NM_001374872 NM_001374873 NM_001374874 NM_025611 RefSeq (protein) NP_001161842 NP_055595 NP_001361801 NP_001361802 NP_001361803 NP_079887 Location (UCSC) Chr 6: 43.04 – 43.05 Mb Chr 17: 46.96 – 46.98 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Clinical significance

It is associated with 3-M syndrome.

Interactions

CUL7 has been shown to interact with RBX1.

Further reading

• Kim SS, Shago M, Kaustov L, et al. (2007). "CUL7 is a novel antiapoptotic oncogene". Cancer Res. 67 (20): 9616–22. doi:10.1158/0008-5472.CAN-07-0644. PMID 17942889.
• Jung P, Verdoodt B, Bailey A, et al. (2007). "Induction of cullin 7 by DNA damage attenuates p53 function". Proc. Natl. Acad. Sci. U.S.A. 104 (27): 11388–93. Bibcode:2007PNAS..10411388J. doi:10.1073/pnas.0609467104. PMC 2040908. PMID 17586686.
• Skaar JR, Florens L, Tsutsumi T, et al. (2007). "PARC and CUL7 form atypical cullin RING ligase complexes". Cancer Res. 67 (5): 2006–14. doi:10.1158/0008-5472.CAN-06-3241. PMID 17332328.
• Kaustov L, Lukin J, Lemak A, et al. (2007). "The conserved CPH domains of Cul7 and PARC are protein-protein interaction modules that bind the tetramerization domain of p53". J. Biol. Chem. 282 (15): 11300–7. doi:10.1074/jbc.M611297200. PMID 17298945.
• Kasper JS, Arai T, DeCaprio JA (2006). "A novel p53-binding domain in CUL7". Biochem. Biophys. Res. Commun. 348 (1): 132–8. doi:10.1016/j.bbrc.2006.07.013. PMID 16875676.
• Andrews P, He YJ, Xiong Y (2006). "Cytoplasmic localized ubiquitin ligase cullin 7 binds to p53 and promotes cell growth by antagonizing p53 function". Oncogene. 25 (33): 4534–48. doi:10.1038/sj.onc.1209490. PMID 16547496. S2CID 36894787.
• Huber C, Dias-Santagata D, Glaser A, et al. (2005). "Identification of mutations in CUL7 in 3-M syndrome". Nat. Genet. 37 (10): 1119–24. doi:10.1038/ng1628. PMID 16142236. S2CID 44003147.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
• Winston JT, Koepp DM, Zhu C, et al. (1999). "A family of mammalian F-box proteins". Curr. Biol. 9 (20): 1180–2. Bibcode:1999CBio....9.1180W. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037. S2CID 14341845.
• Nomura N, Nagase T, Miyajima N, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.

External links

• GeneReviews/NIH/NCBI/UW entry on 3-M syndrome
• OMIM entries entry on 3-M syndrome
• Human CUL7 genome location and CUL7 gene details page in the UCSC Genome Browser.
• Overview of all the structural information available in the PDB for UniProt: Q14999 (Human Cullin-7) at the PDBe-KB.