DBR1

This article is about a human gene. For the automobile, see Aston Martin DBR1.

Lariat debranching enzyme is a protein that in humans is encoded by the DBR1 gene.

DBR1
Identifiers
Aliases	DBR1, debranching RNA lariats 1
External IDs	OMIM: 607024; MGI: 1931520; HomoloGene: 9428; GeneCards: DBR1; OMA:DBR1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3q22.3 Start 138,160,988 bp End 138,174,921 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 E3.3 Start 99,457,852 bp End 99,466,554 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell Achilles tendon tendon of biceps brachii amniotic fluid germinal epithelium gonad epithelium of nasopharynx ganglionic eminence islet of Langerhans ventricular zone Top expressed in primitive streak epiblast abdominal wall hair follicle medial ganglionic eminence trigeminal ganglion maxillary prominence motor neuron endothelial cell of lymphatic vessel mandibular prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function hydrolase activity RNA lariat debranching enzyme activity hydrolase activity, acting on ester bonds metal ion binding RNA binding Cellular component nucleus nucleoplasm Biological process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome mRNA processing RNA phosphodiester bond hydrolysis, endonucleolytic Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51163 83703 Ensembl ENSG00000138231 ENSMUSG00000032469 UniProt Q9UK59 Q923B1 RefSeq (mRNA) NM_016216 NM_031403 NM_001368298 RefSeq (protein) NP_057300 NP_113580 NP_001355227 Location (UCSC) Chr 3: 138.16 – 138.17 Mb Chr 9: 99.46 – 99.47 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The RNA lariat debranching enzyme, or DBR1, specifically hydrolyzes 2-prime-to-5-prime branched phosphodiester bonds at the branch point of excised lariat intron RNA and converts them into linear molecules.[supplied by OMIM]

Further reading

• Chapman KB, Boeke JD (1991). "Isolation and characterization of the gene encoding yeast debranching enzyme". Cell. 65 (3): 483–92. doi:10.1016/0092-8674(91)90466-C. PMID 1850323. S2CID 39225964.
• Arenas J, Hurwitz J (1987). "Purification of a RNA debranching activity from HeLa cells". J. Biol. Chem. 262 (9): 4274–9. doi:10.1016/S0021-9258(18)61343-2. PMID 2435736.
• Martin A, Schneider S, Schwer B (2002). "Prp43 is an essential RNA-dependent ATPase required for release of lariat-intron from the spliceosome". J. Biol. Chem. 277 (20): 17743–50. doi:10.1074/jbc.M200762200. PMID 11886864.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ye Y, De Leon J, Yokoyama N, et al. (2006). "DBR1 siRNA inhibition of HIV-1 replication". Retrovirology. 2: 63. doi:10.1186/1742-4690-2-63. PMC 1266399. PMID 16232320.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.