Wikipedia

Decoy receptor 3

Decoy receptor 3 (Dcr3), also known as tumor necrosis factor receptor superfamily member 6B (TNFRSF6B), TR6 and M68, is a soluble protein of the tumor necrosis factor receptor superfamily which inhibits Fas ligand-induced apoptosis.[3][4][5]

TNFRSF6B
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesTNFRSF6B, DCR3, DJ583P15.1.1, M68, M68E, TR6, tumor necrosis factor receptor superfamily member 6b, TNF receptor superfamily member 6b
External IDsOMIM: 603361; HomoloGene: 48242; GeneCards: TNFRSF6B; OMA:TNFRSF6B - orthologs
Orthologs
SpeciesHumanMouse
Entrez

8771

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Ensembl

ENSG00000243509

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UniProt

O95407

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RefSeq (mRNA)

NM_032945
NM_003823

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RefSeq (protein)

NP_003814

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Location (UCSC)Chr 20: 63.7 – 63.7 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Discovery

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Dcr3 was identified in 1998 by the search of genes with homology to the TNFR gene superfamily in expressed sequence tag (EST) database.

Structure

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The open reading frame of TNFRSF6B encodes 300 amino acids with a 29-residue signal sequence and four tandem cystein-rich repeats. Two transcript variants encoding the same isoform, but differing in the 5' UTR, have been observed for this gene.[5] Unlike most of the other members of TNFR superfamily, TNFRSF6 is a soluble protein which contains no transmembrane domain.

Function

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This gene belongs to the tumor necrosis factor receptor superfamily. It acts as a decoy receptor that competes with death receptors for ligand binding. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death and T cell activation as well as to induce angiogenesis via neutralization of TL1A. Overexpression of this gene has been noted in various tumors e.g. gastrointestinal tract tumors, and it is located in a gene-rich cluster on chromosome 20, with other potentially tumor-related genes.[5]

Interactions

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TNFRSF6B has been shown to interact with:

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000243509 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ a b Pitti RM, Marsters SA, Lawrence DA, Roy M, Kischkel FC, Dowd P, Huang A, Donahue CJ, Sherwood SW, Baldwin DT, Godowski PJ, Wood WI, Gurney AL, Hillan KJ, Cohen RL, Goddard AD, Botstein D, Ashkenazi A (Jan 1999). "Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer". Nature. 396 (6712): 699–703. doi:10.1038/25387. PMID 9872321. S2CID 4427455.
  4. ^ a b c Yu KY, Kwon B, Ni J, Zhai Y, Ebner R, Kwon BS (Jun 1999). "A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis". J Biol Chem. 274 (20): 13733–6. doi:10.1074/jbc.274.20.13733. PMID 10318773.
  5. ^ a b c "Entrez Gene: TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy".
  6. ^ Zhang J, Salcedo TW, Wan X, Ullrich S, Hu B, Gregorio T, Feng P, Qi S, Chen H, Cho YH, Li Y, Moore PA, Wu J (June 2001). "Modulation of T-cell responses to alloantigens by TR6/DcR3". J. Clin. Invest. 107 (11): 1459–68. doi:10.1172/JCI12159. PMC 209323. PMID 11390428.
  7. ^ a b Hsu TL, Chang YC, Chen SJ, Liu YJ, Chiu AW, Chio CC, Chen L, Hsieh SL (May 2002). "Modulation of dendritic cell differentiation and maturation by decoy receptor 3". J. Immunol. 168 (10): 4846–53. doi:10.4049/jimmunol.168.10.4846. PMID 11994433.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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