Frizzled-8

Frizzled-8 (Fz-8) is a protein that in humans is encoded by the FZD8 gene.

FZD8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1IJY, 4F0A
Identifiers
Aliases	FZD8, FZ-8, hFZ8, frizzled class receptor 8
External IDs	OMIM: 606146; MGI: 108460; HomoloGene: 40606; GeneCards: FZD8; OMA:FZD8 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) Band 10p11.21 Start 35,638,247 bp End 35,642,296 bp
Gene location (Mouse) Chr. Chromosome 18 (mouse) Band 18 A1|18 4.91 cM Start 9,212,163 bp End 9,218,136 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone cartilage tissue ganglionic eminence retinal pigment epithelium tendon of biceps brachii trabecular bone lactiferous duct pancreatic epithelial cell pancreatic ductal cell spinal ganglia Top expressed in ventricular zone hypoblast calvaria retinal pigment epithelium left lobe of liver ankle ciliary body molar primitive endoderm trigeminal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transmembrane signaling receptor activity signaling receptor binding ubiquitin protein ligase binding protein binding signal transducer activity PDZ domain binding G protein-coupled receptor activity Wnt-protein binding Wnt-activated receptor activity Cellular component integral component of membrane membrane plasma membrane Golgi apparatus Wnt-Frizzled-LRP5/6 complex Biological process positive regulation of protein phosphorylation positive regulation of JUN kinase activity cell surface receptor signaling pathway G protein-coupled receptor signaling pathway angiogenesis positive regulation of transcription by RNA polymerase II multicellular organism development negative regulation of transcription by RNA polymerase II neuron differentiation signal transduction Wnt signaling pathway T cell differentiation in thymus non-canonical Wnt signaling pathway canonical Wnt signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8325 14370 Ensembl ENSG00000177283 ENSMUSG00000036904 UniProt Q9H461 Q61091 RefSeq (mRNA) NM_031866 NM_008058 RefSeq (protein) NP_114072 NP_032084 Location (UCSC) Chr 10: 35.64 – 35.64 Mb Chr 18: 9.21 – 9.22 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.

Further reading

• Wang Y, Macke JP, Abella BS, Andreasson K, Worley P, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J (1996). "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled". J. Biol. Chem. 271 (8): 4468–4476. doi:10.1074/jbc.271.8.4468. PMID 8626800.
• Finch PW, He X, Kelley MJ, Uren A, Schaudies RP, Popescu NC, Rudikoff S, Aaronson SA, Varmus HE, Rubin JS (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–6775. Bibcode:1997PNAS...94.6770F. doi:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640.
• Tamai K, Semenov M, Kato Y, Spokony R, Liu C, Katsuyama Y, Hess F, Saint-Jeannet JP, He X (2000). "LDL-receptor-related proteins in Wnt signal transduction". Nature. 407 (6803): 530–535. Bibcode:2000Natur.407..530T. doi:10.1038/35035117. PMID 11029007. S2CID 4400159.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Semënov MV, Tamai K, Brott BK, Kühl M, Sokol S, He X (2001). "Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6". Curr. Biol. 11 (12): 951–961. Bibcode:2001CBio...11..951S. doi:10.1016/S0960-9822(01)00290-1. PMID 11448771. S2CID 15702819.
• Dann CE, Hsieh JC, Rattner A, Sharma D, Nathans J, Leahy DJ (2001). "Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains". Nature. 412 (6842): 86–90. Bibcode:2001Natur.412...86D. doi:10.1038/35083601. PMID 11452312. S2CID 4303237.
• Yao R, Maeda T, Takada S, Noda T (2001). "Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled". Biochem. Biophys. Res. Commun. 286 (4): 771–778. doi:10.1006/bbrc.2001.5430. PMID 11520064.
• Omoto S, Hayashi T, Kitahara K, Takeuchi T, Ueoka Y (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539. S2CID 32817238.
• Lu W, Yamamoto V, Ortega B, Baltimore D (2004). "Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth". Cell. 119 (1): 97–108. doi:10.1016/j.cell.2004.09.019. PMID 15454084. S2CID 18567677.

External links

• "Frizzled Receptors: FZD₈". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2014-09-03. Retrieved 2008-12-04.
• Overview of all the structural information available in the PDB for UniProt: Q9H461 (Human Frizzled-8 (FZD8)) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.