ADP-ribosylation factor-binding protein GGA2 is a protein that in humans is encoded by the GGA2 gene .[ 5] [ 6] [ 7]
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly.[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000103365 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030872 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Hirst J, Lui WW, Bright NA, Totty N, Seaman MN, Robinson MS (Apr 2000). "A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome" . The Journal of Cell Biology . 149 (1): 67–80. doi :10.1083/jcb.149.1.67 . PMC 2175106 PMID 10747088 . ^ Boman AL, Zhang CJ, Zhu X, Kahn RA (Apr 2000). "A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi" . Molecular Biology of the Cell . 11 (4): 1241–55. doi :10.1091/mbc.11.4.1241 . PMC 14844 PMID 10749927 . ^ a b "Entrez Gene: GGA2 golgi associated, gamma adaptin ear containing, ARF binding protein 2" .^ Mattera R, Arighi CN, Lodge R, Zerial M, Bonifacino JS (Jan 2003). "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex" . The EMBO Journal . 22 (1): 78–88. doi :10.1093/emboj/cdg015 . PMC 140067 PMID 12505986 . ^ Nielsen MS, Madsen P, Christensen EI, Nykjaer A, Gliemann J, Kasper D, Pohlmann R, Petersen CM (May 2001). "The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein" . The EMBO Journal . 20 (9): 2180–90. doi :10.1093/emboj/20.9.2180 . PMC 125444 PMID 11331584 . ^ Jacobsen L, Madsen P, Nielsen MS, Geraerts WP, Gliemann J, Smit AB, Petersen CM (Jan 2002). "The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding" . FEBS Letters . 511 (1–3): 155–8. doi :10.1016/S0014-5793(01)03299-9 PMID 11821067 . S2CID 21977507 . ^ He X, Chang WP, Koelsch G, Tang J (Jul 2002). "Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2" . FEBS Letters . 524 (1–3): 183–7. doi :10.1016/S0014-5793(02)03052-1 PMID 12135764 . S2CID 42042430 . ^ Wasiak S, Legendre-Guillemin V, Puertollano R, Blondeau F, Girard M, de Heuvel E, Boismenu D, Bell AW, Bonifacino JS, McPherson PS (Sep 2002). "Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics" . The Journal of Cell Biology . 158 (5): 855–62. doi :10.1083/jcb.200205078 . PMC 2173151 PMID 12213833 . ^ Kalthoff C, Groos S, Kohl R, Mahrhold S, Ungewickell EJ (Nov 2002). "Clint: a novel clathrin-binding ENTH-domain protein at the Golgi" . Molecular Biology of the Cell . 13 (11): 4060–73. doi :10.1091/mbc.E02-03-0171 . PMC 133614 PMID 12429846 .
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