GTF2H4

General transcription factor IIH subunit 4 is a protein that in humans is encoded by the GTF2H4 gene.

GTF2H4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5IY9, 5IVW, 5IY7, 5IY8, 5IY6
Identifiers
Aliases	GTF2H4, general transcription factor IIH, polypeptide 4, 52kDa, P52, TFB2, TFIIH, general transcription factor IIH subunit 4
External IDs	OMIM: 601760; MGI: 1338799; HomoloGene: 7090; GeneCards: GTF2H4; OMA:GTF2H4 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p21.33 Start 30,908,207 bp End 30,914,106 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17|17 B1 Start 35,978,622 bp End 35,984,631 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver pituitary gland right hemisphere of cerebellum anterior pituitary left lobe of thyroid gland right lobe of thyroid gland body of uterus tibial arteries right coronary artery apex of heart Top expressed in thymus otic vesicle otic placode spermatocyte epiblast saccule mandibular prominence abdominal wall maxillary prominence ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein kinase activity ATP-dependent activity, acting on DNA DNA-binding transcription factor activity DNA helicase activity protein binding RNA polymerase II CTD heptapeptide repeat kinase activity double-stranded DNA binding ATPase activator activity RNA polymerase II general transcription initiation factor activity Cellular component nucleoplasm transcription factor TFIIH holo complex core TFIIH complex portion of holo TFIIH complex transcription factor TFIIH core complex nucleus transcription factor TFIID complex nuclear speck Biological process termination of RNA polymerase I transcription regulation of transcription, DNA-templated phosphorylation of RNA polymerase II C-terminal domain transcription initiation from RNA polymerase I promoter transcription elongation from RNA polymerase II promoter 7-methylguanosine mRNA capping transcription by RNA polymerase II transcription, DNA-templated cellular response to DNA damage stimulus global genome nucleotide-excision repair transcription-coupled nucleotide-excision repair transcription initiation from RNA polymerase II promoter nucleotide-excision repair, DNA incision DNA repair nucleotide-excision repair nucleotide-excision repair, preincision complex stabilization nucleotide-excision repair, preincision complex assembly nucleotide-excision repair, DNA incision, 5'-to lesion DNA duplex unwinding positive regulation of ATP-dependent activity nucleotide-excision repair, DNA duplex unwinding nucleotide-excision repair, DNA incision, 3'-to lesion transcription elongation from RNA polymerase I promoter Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2968 14885 Ensembl ENSG00000213780 ENSMUSG00000001524 UniProt Q92759 O70422 RefSeq (mRNA) NM_001517 NM_010364 RefSeq (protein) NP_001508 NP_034494 Location (UCSC) Chr 6: 30.91 – 30.91 Mb Chr 17: 35.98 – 35.98 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interactions

GTF2H4 has been shown to interact with:

• GTF2F1,
• MED21,
• POLR2A,
• TATA binding protein,
• Transcription Factor II B, and
• XPB.

See also

• Transcription Factor II H

Further reading

• Jeang KT (1998). "Tat, Tat-associated kinase, and transcription". J. Biomed. Sci. 5 (1): 24–7. doi:10.1007/BF02253352. PMID 9570510.
• Yankulov K, Bentley D (1998). "Transcriptional control: Tat cofactors and transcriptional elongation". Curr. Biol. 8 (13): R447-9. Bibcode:1998CBio....8.R447Y. doi:10.1016/S0960-9822(98)70289-1. PMID 9651670. S2CID 15480646.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Blau J, Xiao H, McCracken S, O'Hare P, Greenblatt J, Bentley D (1996). "Three functional classes of transcriptional activation domain". Mol. Cell. Biol. 16 (5): 2044–55. doi:10.1128/MCB.16.5.2044. PMC 231191. PMID 8628270.
• Drapkin R, Le Roy G, Cho H, Akoulitchev S, Reinberg D (1996). "Human cyclin-dependent kinase-activating kinase exists in three distinct complexes". Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6488–93. Bibcode:1996PNAS...93.6488D. doi:10.1073/pnas.93.13.6488. PMC 39050. PMID 8692842.
• Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science. 274 (5287): 605–10. Bibcode:1996Sci...274..605Z. doi:10.1126/science.274.5287.605. PMID 8849451. S2CID 13266489.
• Parada CA, Roeder RG (1996). "Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain". Nature. 384 (6607): 375–8. Bibcode:1996Natur.384..375P. doi:10.1038/384375a0. PMID 8934526. S2CID 4278432.
• García-Martínez LF, Ivanov D, Gaynor RB (1997). "Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes". J. Biol. Chem. 272 (11): 6951–8. doi:10.1074/jbc.272.11.6951. PMID 9054383.
• Cujec TP, Cho H, Maldonado E, Meyer J, Reinberg D, Peterlin BM (1997). "The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme". Mol. Cell. Biol. 17 (4): 1817–23. doi:10.1128/mcb.17.4.1817. PMC 232028. PMID 9121429.
• Rossignol M, Kolb-Cheynel I, Egly JM (1997). "Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH". EMBO J. 16 (7): 1628–37. doi:10.1093/emboj/16.7.1628. PMC 1169767. PMID 9130708.
• Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5605–10. Bibcode:1997PNAS...94.5605S. doi:10.1073/pnas.94.11.5605. PMC 20825. PMID 9159119.
• García-Martínez LF, Mavankal G, Neveu JM, Lane WS, Ivanov D, Gaynor RB (1997). "Purification of a Tat-associated kinase reveals a TFIIH complex that modulates HIV-1 transcription". EMBO J. 16 (10): 2836–50. doi:10.1093/emboj/16.10.2836. PMC 1169892. PMID 9184228.
• Nekhai S, Shukla RR, Kumar A (1997). "A human primary T-lymphocyte-derived human immunodeficiency virus type 1 Tat-associated kinase phosphorylates the C-terminal domain of RNA polymerase II and induces CAK activity". J. Virol. 71 (10): 7436–41. doi:10.1128/JVI.71.10.7436-7441.1997. PMC 192089. PMID 9311822.
• Cujec TP, Okamoto H, Fujinaga K, Meyer J, Chamberlin H, Morgan DO, Peterlin BM (1997). "The HIV transactivator TAT binds to the CDK-activating kinase and activates the phosphorylation of the carboxy-terminal domain of RNA polymerase II". Genes Dev. 11 (20): 2645–57. doi:10.1101/gad.11.20.2645. PMC 316603. PMID 9334327.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Li XY, Green MR (1998). "The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor". Genes Dev. 12 (19): 2992–6. doi:10.1101/gad.12.19.2992. PMC 317190. PMID 9765201.
• Ping YH, Rana TM (1999). "Tat-associated kinase (P-TEFb): a component of transcription preinitiation and elongation complexes". J. Biol. Chem. 274 (11): 7399–404. doi:10.1074/jbc.274.11.7399. PMID 10066804.

External links

• GTF2H4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)