James Rodríguez (born 1991) is a Colombian footballer.
James Rodríguez may also refer to:
- James Roday Rodriguez (James David Rodriguez, born 1976), American actor
- James H. Rodriguez Elementary, an elementary school in New Mexico, U.S.
- Jaime Rodríguez (born 1959), El Salvadorian footballer
- Jaime Rodríguez Calderón (born 1957), Mexican politician