Circulating auto-antibodies in the human body can target normal parts of the skin leading to disease. This is a list of antigens in the skin that may become targets of circulating auto-antibodies leading to the various types of pemphigus.
| Pemphigus variant | Antibody isotype | Antigen | Molecular weight (KDa) |
|---|---|---|---|
| Mucosal pemphigus vulgaris | IgG | Desmoglein 3 | 130 |
| Mucocutaneous pemphigus vulgaris | IgG | Desmoglein 3 Desmoglein 1 |
130 160 |
| Pemphigus foliaceus | IgG | Desmoglein 1 | 160 |
| Paraneoplastic pemphigus | IgG | Desmoglein 3 Desmoglein 1 BPAG1[nb 1] Plectin Desmoplakin I[nb 2] Desmoplakin II Envoplakin Periplakin Alpha-2-macroglobulin-like-1 |
130 160 230 500 250 210 210 190 170 |
| Drug-induced pemphigus | IgG | Desmoglein 3 Desmoglein 1 |
130 160 |
| Subcorneal pustular dermatosis type of IgA pemphigus | IgA1 | Desmocollin 1 | 110/100 |
| Intraepidermal neutrophilic type of IgA pemphigus | IgA1 | Unknown | |
| Pemphigus erythematosus (Senear–Usher syndrome)[nb 3] | IgG | Desmoglein 1 | 160 |
| Fogo selvagem | IgG | Desmoglein 1 | 160 |
| Pemphigus vegetans | IgG | Desmoglein 3 | 130 |
| Pemphigus vegetans of Hallopeau[nb 4] | IgG | Desmoglein 3 | 130 |
| Pemphigus vegetans of Neumann[nb 4] | IgG | Desmoglein 3 | 130 |
| Pemphigus herpetiformis | IgG | Desmoglein 3 Desmoglein 1 |
130 160 |
Footnotes
edit- ^ Notably not BPAG2
- ^ Desmoplakin I and II autoantibodies have also been reported in Stevens–Johnson syndrome
- ^ Parentheticals are used to indicate other names by which a condition is known. If there are multiple alternative names for a condition, they are separated by commas within the parenthetical.
- ^ a b Pemphigus vegetans of Hallopeau represents a mild form of pemphigus vegetans. Pemphigus vegetans of Neumann represents a severe form of pemphigus vegetans.
See also
edit- List of target antigens in pemphigoid
- List of conditions caused by problems with junctional proteins
- List of immunofluorescence findings for autoimmune bullous conditions
- List of cutaneous conditions
- List of genes mutated in cutaneous conditions
- List of histologic stains that aid in diagnosis of cutaneous conditions
References
edit- Bolognia, Jean L.; et al. (2007). Dermatology. St. Louis: Mosby. ISBN 978-1-4160-2999-1.
- James, William D.; et al. (2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.