NDUFS5

NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 is an enzyme that in humans is encoded by the NDUFS5 gene.

NDUFS5
Identifiers
Aliases	NDUFS5, CI-15k, CI15K, NADH:ubiquinone oxidoreductase subunit S5
External IDs	OMIM: 603847; MGI: 1890889; HomoloGene: 134294; GeneCards: NDUFS5; OMA:NDUFS5 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p34.3 Start 39,026,318 bp End 39,034,636 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 D2.2 Start 123,606,503 bp End 123,611,995 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart left ventricle right auricle optic nerve right frontal lobe Brodmann area 9 nucleus accumbens caudate nucleus anterior pituitary prefrontal cortex Top expressed in sternocleidomastoid muscle right ventricle temporal muscle digastric muscle triceps brachii muscle right kidney medial head of gastrocnemius muscle soleus muscle intercostal muscle interventricular septum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function NADH dehydrogenase (ubiquinone) activity Cellular component mitochondrial inner membrane mitochondrial respiratory chain complex I mitochondrial intermembrane space respirasome membrane mitochondrion Biological process mitochondrial respiratory chain complex I assembly mitochondrial electron transport, NADH to ubiquinone Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4725 595136 Ensembl ENSG00000168653 ENSMUSG00000028648 UniProt O43920 Q99LY9 RefSeq (mRNA) NM_004552 NM_001184979 NM_001030274 RefSeq (protein) NP_001171908 NP_004543 NP_001025445 Location (UCSC) Chr 1: 39.03 – 39.03 Mb Chr 4: 123.61 – 123.61 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Loeffen JL, Triepels RH, van den Heuvel LP, et al. (1999). "cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed". Biochem. Biophys. Res. Commun. 253 (2): 415–22. doi:10.1006/bbrc.1998.9786. PMID 9878551.
• Loeffen J, Smeets R, Smeitink J, et al. (1999). "The human NADH: ubiquinone oxidoreductase NDUFS5 (15 kDa) subunit: cDNA cloning, chromosomal localization, tissue distribution and the absence of mutations in isolated complex I-deficient patients". J. Inherit. Metab. Dis. 22 (1): 19–28. doi:10.1023/A:1005434912463. PMID 10070614. S2CID 22326357.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Triepels RH, Hanson BJ, van den Heuvel LP, et al. (2001). "Human complex I defects can be resolved by monoclonal antibody analysis into distinct subunit assembly patterns". J. Biol. Chem. 276 (12): 8892–7. doi:10.1074/jbc.M009903200. hdl:2066/185667. PMID 11112787.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Huang G, Chen Y, Lu H, Cao X (2007). "Coupling mitochondrial respiratory chain to cell death: an essential role of mitochondrial complex I in the interferon-beta and retinoic acid-induced cancer cell death". Cell Death Differ. 14 (2): 327–37. doi:10.1038/sj.cdd.4402004. PMID 16826196.