Norbudrine

Norbudrine
Clinical data
Other names	Norbutrine; RD-9338; N-Cyclobutylnoradrenaline; N-Cyclobutylnorepinephrine
Drug class	Sympathomimetic; Bronchodilator
Identifiers
	IUPAC name 4-[2-(cyclobutylamino)-1-hydroxyethyl]benzene-1,2-diol;
CAS Number	15686-81-4 ; 13329-35-6 (hydrochloride);
PubChem CID	166575;
ChemSpider	145768;
UNII	8P6T83567P;
ChEMBL	ChEMBL2106796;
CompTox Dashboard (EPA)	DTXSID50864619 ;
Chemical and physical data
Formula	C12H17NO3
Molar mass	223.272 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CC(C1)NCC(C2=CC(=C(C=C2)O)O)O;
	InChI InChI=1S/C12H17NO3/c14-10-5-4-8(6-11(10)15)12(16)7-13-9-2-1-3-9/h4-6,9,12-16H,1-3,7H2; Key:OVTZNVCECJYMDW-UHFFFAOYSA-N;

Norbudrine (INNTooltip International Nonproprietary Name; developmental code name RD-9338), also known as norbutrine (BANTooltip British Approved Name) or as N-cyclobutylnoradrenaline, is a drug of the phenethylamine and catecholamine families described as a sympathomimetic and bronchodilator which was never marketed.^[1]^[2]^[3] It is the N-cyclobutyl analogue of norepinephrine (noradrenaline).^[1]^[4] The drug was first described in the literature by 1966.^[1]

References

^ ^a ^b ^c Elks J (2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer US. p. 1-PA215. ISBN 978-1-4757-2085-3. Retrieved 17 October 2024.
^ List PH, Hörhammer L (2013). Chemikalien und Drogen Teil A: N-Q. Handbuch der Pharmazeutischen Praxis - Vollständige (4.) Neuausgabe (in German). Springer Berlin Heidelberg. pp. 265–266. ISBN 978-3-642-65035-2. Retrieved 17 October 2024.
^ "-drine sympathomimetics" (PDF). The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances 2018 (Stem Book 2018). World Health Organization.
^ "Norbudrine". PubChem. U.S. National Library of Medicine. Retrieved 17 October 2024.

[Elks2014-1] Elks J (2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer US. p. 1-PA215. ISBN 978-1-4757-2085-3. Retrieved 17 October 2024.

[ListHörhammer2013-2] List PH, Hörhammer L (2013). Chemikalien und Drogen Teil A: N-Q. Handbuch der Pharmazeutischen Praxis - Vollständige (4.) Neuausgabe (in German). Springer Berlin Heidelberg. pp. 265–266. ISBN 978-3-642-65035-2. Retrieved 17 October 2024.

[WHO-INN-2018-3] "-drine sympathomimetics" (PDF). The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances 2018 (Stem Book 2018). World Health Organization.

[PubChem-4] "Norbudrine". PubChem. U.S. National Library of Medicine. Retrieved 17 October 2024.

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Norbudrine

References

zproxy.org