Ribonuclease H2 subunit A , also known as RNase H2 subunit A , is an enzyme that in humans is encoded by the RNASEH2A gene .[ 5]
The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNaseH2). The other two subunits are the non-catalytic RNASEH2B and RNASEH2C . RNaseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides . It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes.[ 5]
Clinical significance
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