Shizuo Akira (審良 静男, Akira Shizuo) (born January 27, 1953, in Higashiōsaka)[1] is a professor at the Department of Host Defense, Osaka University, Japan.[2] He has made ground-breaking discoveries in the field of immunology, most significantly in the area of innate host defense mechanisms.
Shizuo Akira | |
|---|---|
 Shizuo Akira | |
| Born | January 27, 1953 |
| Nationality | Japanese |
| Alma mater | Osaka University |
| Known for | Toll-like receptors |
| Awards | Robert Koch Prize (2014) William B. Coley Award (2006) Imperial Prize (2007) Japan Academy Prize (2007) Keio Medical Science Prize (2010) Canada Gairdner International Award (2011) |
| Scientific career | |
| Fields | Immunology;innate host defense mechanisms |
| Institutions | Department of Host Defense, Osaka University, Japan. |
| Website | hostdefense |
Education
editShizuo Akira gained a M.D. in School of Medicine from Osaka University in 1977. In 1984 he earned a PhD from Osaka University. Till 1987, he did post-doctoral research at University of California, Berkeley.[3]
Research
editBesides being one of the world's most-cited scientists,[4] he has also been recognised, in the years 2006 and 2007, for having published the greatest number of ‘Hot Papers’ (11 papers) over the preceding two years. He is the recipient of several international awards, including the Gairdner Foundation International Award (2011), Robert Koch Prize, the Milstein Award (2007), and the William B. Coley Award.[5][6]
Among his greatest discoveries is the demonstration, through the ablation of toll-like receptor (TLR)s genes, that TLRs recognize a discrete collection of molecules of microbial origin, and later the RNA helicases, RIG-I (retinoic-acid-inducible protein I) and MDA5 (melanoma differentiation-associated protein 5).[7] All molecules belong to the pattern recognition receptors, which detects intruding pathogens and initiates antimicrobial responses in the host.[8]
Career history
edit- Clinical Training and Physician (1977–1980)
- Research Fellow, University of California, Berkeley (1985–1987)
- Research Associate (1987–1995), Associate Professor (1995), Institute for Molecular and Cellular Biology, Osaka University
- Professor, Hyogo College of Medicine (1996–1999)
- Professor, Research Institute for Microbial Diseases, Osaka University (1999–present)
- Center Director, Osaka University Immunology Frontier Research Center (2007–present)[9]
Recognition
edit- 2000 Inoue Prize for Science (Inoue Foundation of Science)
- 2001 Hideyo Noguchi Prize (Osaka Science & Technology)
- 2002 Osaka Science Prize (Osaka Science & Technology)
- 2003 Takeda Medical Prize (Takeda Science Foundation)
- 2004 Prize of Princess Takamatsu Cancer Research Fund
- 2004 Robert Koch Prize (Robert Koch Foundation, Germany)
- 2005 The Emperor's Purple Ribbon Medal (Japanese Cabinet Office)
- 2006 Asahi Prize (Asahi Shinbun)
- 2006 William B. Coley Award (Cancer Research Institute, United States)
- 2007 "Hottest Researcher" Thompson Scientific Research Award
- 2007 Uehara Prize (Uehara Memorial Foundation)
- 2007 Imperial Prize and Japan Academy Prize (academics) (Japan Academy)
- 2007 Milstein Award (International Society for Interferon and Cytokine Research)
- 2007 Dunham lecture at Harvard University
- 2007 Doctor of Medical Science at Technical University of Munich
- 2008 Dyer Lecture (National Institute of Health)
- 2009 Marsh Lecture (Feinstein Institutes for Medical Research)
- 2009 Lacey Lecture (Washington University in St. Louis)
- 2009 Foreign associate, National Academy of Sciences
- 2009 Person of Cultural Merit (Japanese Government)
- 2009 Hans Bloemendal Medal (University of Nijmegen, Netherland)
- 2010 Avery-Landsteiner Prize (German Society for Immunology)
- 2010 Keio Medical Science Prize
- 2010 Lifetime honorary member (International Endotoxin and Innate Immunity Society)
- 2011 The Canada Gairdner International Award[10][9]
- 2016 Semantic Scholar AI program ranked Akira as #4 on its list of most influential biomedical researchers.[11]
Missing and rescued
editIn July 2021, Akira went missing while climbing Kannon peak in Tenkawa, Nara Prefecture, on his own. He was found and rescued by police with the help of a police dog.[12]
References
edit- ^ "[ISI Highly Cited Researchers Version 1.1]". Archived from the original on October 19, 2006. Retrieved November 14, 2008.
- ^ "Essential Science Indicators". Archived from the original on May 17, 2008.
- ^ "Akira Lab. Osaka University (IFReC/RIMD)".
- ^ "Highly Cited Researchers (h>100) according to their Google Scholar Citations public profiles | Ranking Web of Universities: Webometrics ranks 30000 institutions". www.webometrics.info.
- ^ "Shizuo Akira M.D. 2007 Milstein Award Laureate". Milstein Awards. 2007. Retrieved May 16, 2015.
- ^ "Shizuo Akira MD, PhD. Recipient of the Canada Gairdner International Award, 2011". Gairdner. 2011. Retrieved May 16, 2015.
- ^ Yoneyama M, Kikuchi M, Natsukawa T, et al. (July 2004). "The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses". Nature Immunology. 5 (7): 730–7. doi:10.1038/ni1087. PMID 15208624. S2CID 34876422.
- ^ Lee MS, Kim YJ (February 2007). "Pattern-recognition receptor signaling initiated from extracellular, membrane, and cytoplasmic space". Molecules and Cells. 23 (1): 1–10. doi:10.1016/S1016-8478(23)07382-X. PMID 17464205.
- ^ a b "Akira Lab. Osaka University (IFReC/RIMD)".
- ^ Author profile sangakukan.jp
- ^ Singh Chawla, Dalmeet Singh (October 17, 2017). "Who's the most influential biomedical scientist? Computer program guided by artificial intelligence says it knows". AAAS. Retrieved September 22, 2020.
- ^ Mizuki Hayashi, Police dog, trainer honored for helping to find missing Osaka University professor, The Mainichi (September 7, 2021).
External links
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