Trace amine-associated receptor 8 is a protein that in humans is encoded by the TAAR8 gene .[ 5] [ 6] [ 7] trace amine-associated receptor that is known to be Gi/o -coupled .[ 8]
In humans, molecular modelling and docking experiments have shown that putrescine fits into the binding pocket of the human TAAR6 and TAAR8 receptors.[ 9]
G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins, supplied by OMIM [ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000146385 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000100186 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, et al. (September 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene . 275 (1): 83–91. doi :10.1016/S0378-1119(01)00651-5 . PMID 11574155 . ^ Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC (March 2005). "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors". Genomics . 85 (3): 372–85. doi :10.1016/j.ygeno.2004.11.010 . PMID 15718104 . ^ a b "Entrez Gene: TAAR8 trace amine associated receptor 8" .^ Mühlhaus J, Dinter J, Nürnberg D, Rehders M, Depke M, Golchert J, et al. (November 2014). "Analysis of human TAAR8 and murine Taar8b mediated signaling pathways and expression profile" . International Journal of Molecular Sciences . 15 (11): 20638–55. doi :10.3390/ijms151120638 PMC 4264187 PMID 25391046 . ^ Izquierdo C, Gómez-Tamayo JC, Nebel JC, Pardo L, Gonzalez A (January 2018). "Identifying human diamine sensors for death related putrescine and cadaverine molecules" . PLOS Computational Biology . 14 (1): e1005945. Bibcode :2018PLSCB..14E5945I . doi :10.1371/journal.pcbi.1005945 PMC 5783396 PMID 29324768 .
