TINAGL1

Tubulointerstitial nephritis antigen-like is a protein that in humans is encoded by the TINAGL1 gene.

TINAGL1
Identifiers
Aliases	TINAGL1, ARG1, LCN7, LIECG3, TINAGRP, tubulointerstitial nephritis antigen like 1
External IDs	OMIM: 616064; MGI: 2137617; HomoloGene: 41472; GeneCards: TINAGL1; OMA:TINAGL1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p35.2 Start 31,576,485 bp End 31,587,686 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 D2.2 Start 130,058,247 bp End 130,068,915 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right coronary artery ascending aorta popliteal artery tibial arteries Descending thoracic aorta apex of heart left coronary artery right lobe of thyroid gland left lobe of thyroid gland left uterine tube Top expressed in granulocyte ascending aorta decidua yolk sac external carotid artery umbilical cord endothelial cell of lymphatic vessel pyloric antrum aortic valve tunica media of zone of aorta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function scavenger receptor activity polysaccharide binding cysteine-type endopeptidase activity laminin binding extracellular matrix structural constituent protein binding cysteine-type peptidase activity Cellular component cytoplasm extracellular matrix extracellular region lysosome extracellular exosome extracellular space collagen-containing extracellular matrix Biological process endosomal transport cell adhesion proteolysis involved in cellular protein catabolic process receptor-mediated endocytosis immune response proteolysis endocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64129 94242 Ensembl ENSG00000142910 ENSMUSG00000028776 UniProt Q9GZM7 Q99JR5 RefSeq (mRNA) NM_001204414 NM_001204415 NM_022164 NM_001168333 NM_023476 RefSeq (protein) NP_001191343 NP_001191344 NP_071447 NP_001161805 NP_075965 Location (UCSC) Chr 1: 31.58 – 31.59 Mb Chr 4: 130.06 – 130.07 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Brömme NC, Wex T, Wex H, et al. (2000). "Cloning, characterization, and expression of the human TIN-ag-RP gene encoding a novel putative extracellular matrix protein". Biochem. Biophys. Res. Commun. 271 (2): 474–80. doi:10.1006/bbrc.2000.2639. PMID 10799322.
• Jiang LQ, Wen SJ, Wang HY, Chen LY (2003). "Screening the proteins that interact with calpain in a human heart cDNA library using a yeast two-hybrid system". Hypertens. Res. 25 (4): 647–52. doi:10.1291/hypres.25.647. PMID 12358155.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Umeyama H, Iwadate M, Taguchi YH (2014). "TINAGL1 and B3GALNT1 are potential therapy target genes to suppress metastasis in non-small cell lung cancer". BMC Genomics. 15 (Suppl 9): S2. doi:10.1186/1471-2164-15-S9-S2. PMC 4290609. PMID 25521548.
• Bosse K, Haneder S, Arlt C, Ihling CH, Seufferlein T, Sinz A (2016). "Mass spectrometry-based secretome analysis of non-small cell lung cancer cell lines". Proteomics. 16 (21): 2801–2814. doi:10.1002/pmic.201600297. PMID 27569058. S2CID 38155519.