| State | County | Location | mi | km | Exit[1] | Destinations | Notes |
|---|---|---|---|---|---|---|---|
| Texas | Hidalgo | Penitas | 0.00 | 0.00 |   US 83 west | Western terminus | |
| | 1.09 | 1.75 | 130 | Showers Road | |||
| Palmview | 2.59 | 4.17 | 131 |  FM 492 (Goodwin Road) / Abram Road | |||
| 4.45 | 7.16 | 133 |  SH 364 (La Homa Road) / Bentsen Palm Drive | ||||
| Mission | 5.76 | 9.27 | 134 |  Bus. US 83 / Inspiration Road | |||
| 6.37 | 10.25 | 135 | Los Ebanos Road | Westbound direction bridge over the railway under construction as of July 2015 | |||
| 7.51 | 12.09 | 136 |     SH 107 north / FM 1016 south (Conway Avenue) | ||||
| 8.53 | 13.73 | 137 |  FM 396 (Bryan Road / Anzalduas Highway) | ||||
| 10.01 | 16.11 | 138 |  FM 494 (Shary Road) | ||||
| McAllen | 11.56 | 18.60 | 140 |  FM 2220 (Ware Road) | |||
| 12.59 | 20.26 | 141 |   Spur 115 (23rd Street) / Main Street – Airport | ||||
| 13.54 | 21.79 | 142 |  SH 336 (10th Street) / Main Street / 2nd Street – Airport | ||||
| 14.64 | 23.56 | 143A | McColl Road / 2nd Street | No direct westbound exit (signed at exit 143B) | |||
| 14.99 | 24.12 | 143B | Jackson Avenue / Sam Houston Avenue | ||||
| McAllen–Pharr line | 15.66 | 25.20 | 144 |   Bus. US 83 / FM 2061 / FM 3362 (Jackson Road) | |||
| Pharr | 16.42 | 26.43 | 145 | Sugar Road / Polk Avenue | |||
| 17.22 | 27.71 | 146 |    I-69C north / US 281 – Edinburg, Pharr | Signed as exits 146A (south) and 146B (north); I-69C exits 1A-B | |||
| 146C | Frontage Road | Extra eastbound exit; other access is at adjacent interchanges | |||||
| Pharr–San Juan line | 18.24 | 29.35 | 147A | Veterans Boulevard | |||
| San Juan | 18.72 | 30.13 | 147B |  FM 1426 – San Juan | |||
| 20.40 | 32.83 | 149 |  FM 2557 south (Stewart Road) / Cesar Chavez Road | Direct access to FM 2557 eastbound only | |||
| Alamo | 21.15 | 34.04 | 150A |  FM 907 (Alamo Road) | |||
| 21.90 | 35.24 | 150B | Tower Road | ||||
| Donna | 23.41 | 37.67 | 152 |  FM 1423 (Val Verde Road) | |||
| 24.66 | 39.69 | 153 | Hutto Road | ||||
| 25.52 | 41.07 | 154 |  Spur 433 (Main Street) | ||||
| 26.23 | 42.21 | 155A |  FM 493 (Salinas Boulevard) | ||||
| | 27.03 | 43.50 | 155B | Victoria Road / Midway Road | |||
| Weslaco | 28.42 | 45.74 | 157 | Westgate Drive / Mile 6 West Road | |||
| 29.42 | 47.35 | 158 |  FM 88 (Texas Boulevard) | ||||
| 30.45 | 49.00 | 159 | Airport Drive / Pike Boulevard | Serves Mid Valley Airport | |||
| 31.64 | 50.92 | 160 |  FM 1015 (International Boulevard) | ||||
| Mercedes | 32.79 | 52.77 | 161 |  Spur 31 (Mile 2 West Road) | |||
| 34.19 | 55.02 | 163A | Vermont Avenue | ||||
| 34.64 | 55.75 | 163B |  FM 491 (Texas Avenue) | ||||
| 35.87 | 57.73 | 164 | Mile 1 East Road | ||||
| 36.88 | 59.35 | 165 |  FM 1425 (Mile 2 East Road) | ||||
| Hidalgo–Cameron county line | 37.87 | 60.95 | 166 | Mile 3 East Road | |||
| Cameron | La Feria | 39.09 | 62.91 | 167 |  FM 2556 (Solis Road) | No direct westbound exit (signed at exit 166) | |
| 39.52 | 63.60 | 168 | Rabb Road | no direct eastbound exit (signed at exit 167) | |||
| 40.29 | 64.84 | 169 |  FM 506 – La Feria, Santa Rosa | ||||
| | 40.97 | 65.93 | 170 |  FM 733 (Kansas City Road) / White Ranch Road | |||
| Harlingen | 42.93 | 69.09 | 171 |  FM 800 (Bass Boulevard) | |||
| 43.90 | 70.65 | 172 | Altas Palmas Road | ||||
| 44.75 | 72.02 | 173 |  FM 3195 (Stuart Place Road) | ||||
| 46.50 | 74.83 | 174 | Bus. US 83 west (Spur 54 east) / Lewis Lane | ||||
| 47.04 | 75.70 | 175 | Tyler Avenue (Spur 206 east) / Dixieland Road / Bass Pro Drive - Downtown Harlingen | Eastbound exit and westbound entrance | |||
| 47.31 | 76.14 | 176A |   I-69E north / US 77 north – Raymondville, Corpus Christi, Airport | Eastbound exit and westbound entrance; I-69E exit 26B | |||
| 47.31 | 76.14 | 176B |  I-69E south / US 77 south / US 83 south – Brownsville | ||||
| 1.000 mi = 1.609 km; 1.000 km = 0.621 mi | |||||||
- ^ Texas Department of Transportation, plans of proposed highway maintenance contract (1.58 GB ZIP file), December 2014