Wolfram may refer to:
- Wolfram (name), a Germanic masculine given name and a surname (includes a list of people with the name)
- Wolfram (musician), an Austrian DJ
- Wolfram (element), the original name for the chemical element best known as tungsten
- Wolfram Research, a software company known for the symbolic computation program Mathematica
- Wolfram Language, the programming language used by Mathematica
- Wolfram code, a naming system for one-dimensional cellular automaton rules introduced by Stephen Wolfram
- Wolfram syndrome, a genetic disorder
- Wolfram, Queensland, a former mining town in Australia
- The Wolfram, a fictional military airship in the air combat video game The Sky Crawlers: Innocent Aces